Antimicrobial efficacy of non-fluoride toothpaste on isolated oral microbes – an in vitro study.


  • Mike Eghosa OGBEIDE Department of Dental and Maxillofacial Surgery, Usmanu Danfodiyo University Teaching Hospital, Sokoto,
  • Adedoyin Odunayo ADEBOWALE Department of Periodontology and Community Dentistry, University College Hospital, Ibadan, Nigeria


Efficacy, Antimicrobia, non flouride, oral microbes, in vitro


Objective: To evaluate the Antimicrobial Efficacy of
Non-Fluoride Toothpaste on Isolated Oral Microbes
Method: The antimicrobial activity of the non-fluoride
toothpaste against isolated oral microbes was
determined by dilution method at neat dilution, 1/2, 1/4,
1/8 and 1/16.
Results: Study results showed that Streptococcus spp
was resistant while the maximum zone of inhibition was
on Lactobacilli spp. It was also observed that zone of
inhibition decreases with the increase in dilution except
for Streptococcus spp.
Conclusion: This study revealed that while the nonfluoride
toothpaste containing mainly triclosan and
natural extract was significantly effective against most
isolated oral microbes causing oral diseases it however,
showed little or no effect against Streptococcus spp
which is primarily involved in caries initiation.